Dr. Mohit Dubey

PhD Neuroscience, Department of Child Neurology, VU University Amsterdam, The Netherlands.
Masters of Science in Pharmacology, University of Oxford, UK.
Bachelor of Pharmacy, Guru Gobind Singh IP Univ, New Delhi, India.
In more than 20 years of formal education and research, Dr Mohit Dubey has extensive experience in pharmacology to neuroscience, neurons to neuron-glia physiology, and from ion selective microelectrodes to radio-transmission based electrophysiology (brain electrical recordings). Currently, He is developing two-photon laser scanning microscopy with state of the art neuropixels (next generation electrodes) and optogenetic recordings at the Netherlands Institute for Neuroscience, Royal Netherlands Academy of Science. He has independently established many of these techniques at the respective institutes. All of his research activities are driven by the questions to understand the complex neurological diseases connecting the lab bench to clinics.

During his PhD-project, under supervision of Prof .Dr. Marjo van de Knaap (Amsterdam UMC, location VuMC) and Prof. Dr. Huib Mansvelder (CNCR, Amsterdam) he studied and validated two genetic models of a rare human brain disorder. He studied a complex interaction of astrocytes and oligodendrocytes with neurons and discovered that astrocytic dysfunction is cardinal to observed neuronal disease phenotype. He independently developed radio-telemetry EEG-LFP system and ion selective microelectrodes recordings to unravel impaired astrocytic volume regulation resulting in disturbed potassium homeostasis in brain. For EEG data analysis he set up collaboration with Prof. Dr. Dimitri Kullmann lab at the Department of experimental epilepsy, Institute of Neurology, London. His PhD work resulted in two papers in Annals of Neurology (one of them featured as front cover) and one paper in Annals of clinical and translational neurology. His expertise in epilepsy resulted in a co-authored paper (published in Brain) with Prof. Dr. Matthijs Verhagen (CNCR, Amsterdam).